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X Chromosome Inactivation in Opioid Addicted Women
Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome. Here we have investigated XCI ratio in females with opioid addiction to see whether XCI skewness in women could be a risk factor for opioid addiction. Methods: 30 adult females meeting DS...
full textX-chromosome inactivation
It is a well-known fact of popular science that nearly all tortoiseshell cats are female. Underlying this is X-chromosome inactivation, a phenomenon found in all mammals. In the sex-determining system of mammals — in which females carry two X chromosomes and males an X and a Y chromosome — the X chromosome is typically large and carries many genes unconnected with sex, whereas the Y chromosome ...
full textx chromosome inactivation in opioid addicted women
introduction: x chromosome inactivation (xci) is a process during which one of the two x chromosomes in female human is silenced leading to equal gene expression with males who have only one x chromosome. here we have investigated xci ratio in females with opioid addiction to see whether xci skewness in women could be a risk factor for opioid addiction. methods: 30 adult females meeting dsm iv ...
full textX-chromosome inactivation and autoimmunity
We thank Dr Ozcelik for his careful reading of our review and his thoughtful letter. Dr Ozcelik raises the issue of nonequivalence of monosomy X frequency and X-chromosome inactivation pattern (XCIP). The first refers to the proportion of cells with a single X chromosome, wherein transcription occurs from the lone X chromosome. The second refers to the ratio of inactivated maternal to paternal ...
full textX-chromosome inactivation and autoimmunity
We thank Dr Ozcelik for his careful reading of our review and his thoughtful letter. Dr Ozcelik raises the issue of nonequivalence of monosomy X frequency and X-chromosome inactivation pattern (XCIP). The first refers to the proportion of cells with a single X chromosome, wherein transcription occurs from the lone X chromosome. The second refers to the ratio of inactivated maternal to paternal ...
full textTissue specificity of X-chromosome inactivation patterns.
The analysis of X-chromosome inactivation patterns has been used in a number of clinical situations such as the identification of carrier status in X-linked genetic disorders and the establishment of the monoclonal origin of tumors. Interpretation of the result obtained requires comparison with the constitutive pattern for the individual, and for hematopoietic malignancies, skin biopsies or cul...
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Journal title:
genetics in the 3rd millenniumجلد ۲، شماره ۱، صفحات ۳۰۷-۳۱۲
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